Informative.Awareness
These are toxicants that cause severe to moderately severe adverse effects on single exposure. The effects are oftentimes seen within hrs or few days after exposure.
Toxicology Bipyridyl (or bipyridinium) herbicides are quaternary ammonium compounds marketed as contact herbicides and desiccants (Eddleston M. 2016). Bipyridyl herbicides-diquat and paraquat-exist as divalent cations found as dibromide or dichloride …
Read MoreToxicology Beta-blockers act as competitive inhibitors of catecholamines at both central and peripheral receptors. Blockade of beta-receptors results in decreased production of intracellular cAMP which in turn suppresses multiple metabolic …
Read MoreToxicology Superwarfarins such as brodifacoum, bromadiolone, chlorophacinone, difenacoum and difethialone are long acting, odourless, tasteless and colourless hydroxycoumarin rodenticides. They affect regeneration of Vit K. Reduced vitamin K (hydroquinone) is a …
Read MoreToxicology Antihistamines (H1 receptor antagonists) are commonly found in medications used for motion sickness, control of allergy-related itching and sleep aids. H1 blocker antihistamines are structurally related to histamine and inhibit the …
Read MoreToxicology The possible mechanisms of naphthoquinone-induced toxicity is through extensive depletion of intracellular glutothion (GSH). Dicoumarol compound potentiates its cytotoxicity. Depletion of GSH results from the propensity for naphthoquinones to …
Read MoreToxicology includes Pyrifluquinazon and Fenazaquin Fenazaquin is moderately acutely toxic (LD50 134-138 mg/kg ) (EPA, 2007) Most of ingested fenazaquin is excreted primarily in the feces and a little in …
Read MoreToxicology Cabamazepne is an antiepileptic drug also used for treatment of trigeminal neuralgia, and bipolar affective disorder. Its absorption is erratic with a peak plasma levels in 4-8 hours postingestion. …
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• Fenazaquin is moderatelyacutely toxic (LD50 134/138 mg/kg ) (EPA, 2007) • Most of ingested fenazaquin is excreted primarily in the excreta and a little in the urine, mostly as …
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