Toxicology
- The possible mechanisms of naphthoquinone-induced toxicity is through extensive depletion of intracellular glutothion (GSH). Dicoumarol compound potentiates its cytotoxicity. Depletion of GSH results from the propensity for naphthoquinones to undergo redox cycling and to bind covalently to cellular nucleophiles such as GSH,NADPH and Oxygen. NADPH-cytochrome p450 reductase is thought to be responsible for naphthoquinone-stimulated redox cycling (Miller et al., 1986).
- Acequinocyl , a structural analogue of ubiquinone, acts by inhibiting electron transfer in the mitochondria of spider mites thereby blocking cellular respiration at membrane level. It inhibits the Qo centre of Complex . . .
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