Toxicology
- Antihistamines (H1 receptor antagonists) are commonly found in medications used for motion sickness, control of allergy-related itching and sleep aids.
- H1 blocker antihistamines are structurally related to histamine and inhibit the effects of histamine on H1 receptor sites.
- The pathophysiology of antihistamine toxicity varies as the drug has a wide range of therapeutic and toxic effects.
- Most commonly, ingestion of H1 antihistamines (such as diphenhydramine) manifests with hallucinations or antimuscarinic effects.
- H1 blockers have anticholinergic effects (except the “nonsedating” cetirizine, desloratadine, fexofenadine, levocetirizine, and loratadine) (Drugs.com;Medscape . . .
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