Toxicology
- Superwarfarins such as brodifacoum, bromadiolone, chlorophacinone, difenacoum and difethialone are long acting, odourless, tasteless and colourless hydroxycoumarin rodenticides. They affect regeneration of Vit K. Reduced vitamin K (hydroquinone) is a cofactor in the carboxylation of amino-terminus glutamic acid in clotting factors II (prothrombin), VII, IX, and X and the anticoagulant proteins C and S factors (by hepatic γ-glutamyl carboxylase). The carboxylation process causes oxidation of vitamin K to an epoxide. Vitamin K eposide is reduced back to hydroquinone in a two step process involving Vitamin K 2, 3 epoxide reductase and vitamin K quinone reductase to . . .
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