Toxicology
- Beta-blockers act as competitive inhibitors of catecholamines at both central and peripheral receptors. Blockade of beta-receptors results in decreased production of intracellular cAMP which in turn suppresses multiple metabolic and cardiovascular effects of circulating catecholamines. Myocardial conduction delays with decreased contractility mostly describe acute beta-blocker ingestion.
- Beta1-receptor blockade decreases heart rate, blood pressure, myocardial contractility, and myocardial oxygen consumption. Beta 2-receptor blockade inhibits relaxation of smooth muscle in blood vessels, bronchi, the gastrointestinal system, and the genitourinary tract.
- Beta-adrenergic receptor blockers inhibits both glycogenolysis and gluconeogenesis, thereby . . .
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