Toxicology
Cabamazepne is an antiepileptic drug also used for treatment of trigeminal neuralgia, and bipolar affective disorder.
Its absorption is erratic with a peak plasma levels in 4-8 hours postingestion. The peak serum levels with controlled-release formulations of carbamazepine can result in peak for 96 hours postingetion. The onset of toxic effects are thus delayed.
Carbamazepine is metabolized by the cytochrome P450 system into active metabolites such as carbamazepine-10,11-epoxide which are conjugated with glucuronic acid before renal excretion. This active metabolite increases duration of the symptoms of toxicity.
The mechanism of action of carbamazepine reduces . . .
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