Erythromycin and Congeners: A Toxicologist’s Perspective.

Erythromycin and its congeners including erythromycin, azithromycin and clarithromycin belong to the antibiotic class called macrolides.  

Macrolide antibiotics are among the most commonly prescribed antibiotics worldwide and are used for a wide range of infections.  

First-line indications for macrolides include the treatment of atypical community acquired pneumonia, H. Pylori (as part of triple therapy), chlamydia, pertussis (by Bordetella pertussis) and acute non-specific urethritis.  

Clarithromycin and azithromycin (2nd generation macrolides) have a better pharmacokinetic profile and are more active than erythromycin against target organisms.  

Macrolides are also a useful alternative for people with penicillin and cephalosporin allergy. 

Macrolides also . . .

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