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Specific Management

Acute Toxic Agents / Chemical Class / Specific Management

PHENYLAMIDES

November 5, 2017June 10, 2023 - by Poison Sense

Toxicology • The cardiotoxic effects is mediated by alpha 1-adrenoreceptor activity since it is blocked by alpha 1-adrenoreceptor antagonist sauch as phentolamine (a nonselective alpha-adrenoreceptor antagonist) and prazosin (an alpha …

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Acute Toxic Agents / Chemical Class / Specific Management

THIOCARBAMATES

November 5, 2017June 10, 2023 - by Poison Sense

Toxicology • As a chemical family, the thiocarbamates are a group of pesticides with a wide range of uses. Some are used as fungicides, while others have herbicidal activity (Fishel …

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Acute Toxic Agents / Chemical Class / Specific Management

BARBITURATES

November 5, 2017June 8, 2023 - by Poison Sense

Toxicology At low doses, barbiturates bind to GABA-sensitive ion channels in CNS, leading increased influx of chloride ions into cell membranes where they produce hyperpolarization of post synaptic neurone (Lafferty …

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Acute Toxic Agents / Chemical Class / Specific Management

DINITROANILINE

November 5, 2017December 7, 2025 - by Poison Sense

Toxicology • Exposure route is by inhalation of its aerosol, through the skin and by ingestion (National Center for Biotechnology Information, 2015) • Oral exposure to rats showed low toxicity …

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Acute Toxic Agents / Chemical Class / Specific Management

ORGANOCHLORINE

November 5, 2017June 8, 2023 - by Poison Sense

Toxicology • The organochlorine (OCs) insecticides belong to three distinct chemical classes including the dichlorodiphenylethane, chlorinated cyclodiene and chlorinated benzene cyclohexane-related structures (Ecobichon DJ, 2008). • The LD50s of OCs …

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Acute Toxic Agents / Chemical Class / Specific Management

TRIFLUOROMETHYL AMINOHYDRAZONE

November 5, 2017June 8, 2023 - by Poison Sense

 Toxicology • Hydramethylnon acts by disrupting energy production in the cells. It works by inhibiting complex III in the mitochondrial inner membrane and leads to a halting of oxidative phosphorylation. …

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Acute Toxic Agents / Chemical Class / Specific Management

NICOTINE

October 31, 2017October 27, 2026 - by Poison Sense

Toxicology Acute nicotine poisoning may occur through ingestion of tobacco or other products containing nicotine (such as pesticides or nicotine-replacement medications) or through absorption of nicotine through the skin, either …

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Acute Toxic Agents / Chemical Class / Specific Management

SUBSTITUTED UREA

October 31, 2017June 8, 2023 - by Poison Sense

Toxicology • The urea-derivatives are typical pre-emergence herbicides applied usually as aqueous emulsions to the surface of soil. Almost all of the urea compounds with good herbicidal action are trisubstituted …

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Acute Toxic Agents / Chemical Class / Specific Management

STROBILURINS

October 31, 2017June 8, 2023 - by Poison Sense

Toxicology • Inhibits cytochrome complex and thus antagonizes electron transfer that finally causes inhibition of mitochondrial respiration( Roberts and Reigart, 2013) • They produce relatively low toxicity; most strobilurins report …

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Acute Toxic Agents / Chemical Class / Specific Management

IRON SALTS

October 31, 2017June 8, 2023 - by Poison Sense

Toxicology Acute iron toxicity is usually seen in children less than 5 years of age  who present with accidental ingestion of iron supplements. The main causes of iron poisoning in adults …

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Hi, I am Dr. Bundo, Msc in pharmacology and Toxicology.
This site is here to bring clinical toxicology information to the public domain.

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