Toxicology
• Clofentezine is an acaricide with low mammalian toxicity (Oral LD50 > 5000 mg/kg)(IPCS, 2005;AAKO, 2006).
• Its mode of toxicity is not understood(IPCS, 2005).
• At high doses causes liver enzyme induction (IPCS, 2005)
• Studies in laboratory animals indicated that clofentezine was excreted predominantly in the feaces, 50% of the fecal component was unchanged (IPCS, 2005).
• Oral doses of clofentezine are quickly absorbed from the gut lumen, peak plasma levels in occurrs 4-6 hrs post ingestion (IPCS, 2005)
Clinical Manifestation
• Oral exposure to rats produced very slight salivation and slight urinary incontinence (IPCS, 2005).
• No know . . .
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