Toxicology
• The mammalian pharmacokinetic studies showed that prothioconazole was rapidly and extensively (> 90%) absorbed from the gastrointestinal tract, the tmax being 0.1–0.7hrs(FAO;D.B. McGregor DB and Soleck R, 2008;National Center for Biotechnology Information)
• The mammalian studies also showed that prothioconazole is extensively metabolized and excreted relatively rapidly mainly via the faeces(FAO;D.B. McGregor DB and Soleck R, 2008;National Center for Biotechnology Information).
• The acute toxicity of prothioconazole is low (oral LD 50 being > 6200 mg/kg bw in rats)(FAO)
• The most affected organs in laboratory acute toxicity studies . . .
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