Toxicology
Acute nicotine poisoning may occur through ingestion of tobacco or other products containing nicotine (such as pesticides or nicotine-replacement medications) or through absorption of nicotine through the skin, either from exposure to pesticides, unprocessed tobacco leaves or nicotine replacement medications.
• The toxicity of nicotine is a result of its stimulation of nicotinic acetylcholine receptors in the central nervous system and peripheral nervous system (Landoni JH, 1991;The Official Newsletter of the CPCS 2005)
• Nicotine toxicity are dose-dependent. It shows dual-phase effect depending on dose;initially stimulatory effects progress to inhibitory actions on various central and peripheral . . .
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