Toxicology
• The urea-derivatives are typical pre-emergence herbicides applied usually as aqueous emulsions to the surface of soil. Almost all of the urea compounds with good herbicidal action are trisubstituted ureas, containing a urea bridge substituted by triazine, benzothiazole, sulfonyl, phenyl, alkyl or other moieties containing a free imino-hydrogen though to be responsible for mode of action through hydrogen bonding(Morais et al 2011)
• The substituted urea herbicides induce hepatic microsomal enzymes and may alter metabolism of other xenobiotic agents. • Some of urea-derivatives oxidizes the ferrous form of iron (Fe2+) in the heme molecule to the ferric . . .
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