Toxicology
The commonly used herbicides are alachlor, acetochlor, butachlor, metolachlor, and propachlor. This class of herbicides is slightly hazardous, except butachlor, which is not likely to pose any hazard.
Chloroacetanilides display moderate to low acute toxicity, with oral LD50 in rat ranging from about 600 mg/kg (propachlor) to 2800 mg/kg (metolachlor) (Costa GL 2008).
Substituted anilines are well absorbed in rats orally. The dermal penetration in monkeys is relatively slow. The metabolism of alachlor in rats is complex due to extensive biliary excretion, intestinal microbial metabolism, and enterohepatic circulation of metabolites. The main route of excretion is urine . . .
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