Toxicology
• Inhibits cytochrome complex and thus antagonizes electron transfer that finally causes inhibition of mitochondrial respiration( Roberts and Reigart, 2013)
• They produce relatively low toxicity; most strobilurins report LD50 of over 5000mg/kg bwt except orysastrobin and metominostrobin, with LD 50 of 356 mg/kg and 708 mg/kg, respectively( Roberts and Reigart, 2013).
•Typically produces irritation of mucus membranes and the skin
Clinical Manifestation
• Upper respiratory tract irritation and pain
• Weakness
• Dizziness
• Chest pain
• Mild dermal and mucus membranous irritation
• Burning of mucus mrmbranes and abdominal upsets after ingestion
Clinical Management
• Provide supportive care directed at symptomatic.
• Consider skin . . .
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