Toxicology
• Hydramethylnon acts by disrupting energy production in the cells. It works by inhibiting complex III in the mitochondrial inner membrane and leads to a halting of oxidative phosphorylation. The inhibition also causes the formation of superoxide and other reactive oxygen species which are highly toxic (NPIC;Wikipedia, 2015;Wikipedia B, 2015)
• Hydramethylnon techinical grade is slightly toxic via ingestion and dermal route. It reported an oral LD50 of 1100-1300 mg/kg in rats (EXTOXNET, 1996)
• Most hydramethylnon is excreted by the anal route(upto 98%) and about 2% with urine , mostly unchanged(NPIC)
• Acute exposure to the techinical . . .
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