Oxyclozanide is a salicylanilide anthelmintic used mainly in ruminants such as cattle, sheep, and goats to treat liver fluke infections (fascioliasis)
After oral administration, oxyclozanide is slowly absorbed into the bloodstream. Maximum blood concentrations in sheep and cattle are reached about 24 hours after treatment (Parasitipedia.net, 2017).
Oxyclozanide binds strongly and almost completely (>99%) to plasma proteins (Parasitipedia.net, 2017).
Oxyclozanide is extensively metabolized in the liver and excreted primarily via bile and faeces (Committee for Veterinary Medicinal Products,1998).
The most affected organ is the liver. However, Histopathological changes were observed in the hearts, livers . . .
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