- Carbamazepine is an iminostilbene derivative that is structurally similar to tricyclic antidepressants.
- Carbamazepine was first indicated for trigeminal neuralgia and later found to be effective against simple partial seizures and complex partial seizures. Extended-release carbamazepine is also indicated for bipolar disorder; adjunct for acute phase of schizophrenia refractory to antipsychotics; restless leg syndrome, peripheral neuropathy, diabetic peripheral neuropathy, and posttraumatic stress disorders.
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Carbamazepine blocks presynaptic voltage-gated sodium channels in a rate dependent manner. The high-frequency nerves such as epileptic foci . . .
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