Informative.Awareness
This is the category based on a number of factors including chemical structure or the mechanism of action or toxicity.
INFORMATION that is provided includes the toxicology of the compounds in this class, as well as the clinical manifestations and management of acute toxicity.
Toxicology • Pyrethroids are synthetic derivatives of natural pyrethrins. Pyrethroids can be Type I(e.g., allethrin, resmethrin, D-phenothrin, and permethrin) or Type II (e.g., deltamethrin, cypermethrin, cyfluthrin and fenvalerate) based on …
Read MoreToxicology • Clomazone and isoxaflutole exhibits low mammalian toxicity, the acute oral LD50 was estimated to be greater than 2000 mg/kg b (Shah PV and Solecki RA, 2013;Van SAR and …
Read MoreToxicology Calcium channel blockers (CCBs) are generally classified into two groups: dihydropyridines (nifedipine, nicardipine, amlodipine,clevidipine etc) and non-dihydropyridines (verapamil, diltiazem). Calcium has a prominent role in cardiovascular function. The flow …
Read MoreToxicology • Methyl bromide is highly toxic(ATSDR, 1992). • Methyl bromide is odorless and nonirritating, a lacrimator (an agent that irritates the eyes and causes tearing), chloropicrin, is often added …
Read MoreToxicology • Sulfur has low toxic potential (rat oral LD50 of greater than 5,000 mg/kg), and poses very little if any risk to human and animal health (Extoxnet, 1995) • …
Read MoreToxicology • The primary routes of arsenic exposure are ingestion and inhalation (HPA, 2007;ATSDR, 2009) • The more efficiently absorbed forms of arsenic the more toxic it is, while those …
Read MoreToxicology • Oxyfluorfen inhibits hemoglobin synthesis at concentration that have no adverse effect on cellular proliferation (NLM HSDB database, 2007) • Diphenyl ether herbicides are protox inhibitors ie inhibit protophorphyrinogen …
Read MoreToxicology • Hexythiazox is rapidly absorbed, distributed and excreted primarily in faeces ( about 70%)while the rest in urine(IPCS Inchem;EFSA, 2010) • The oral absorption has been estimated at 30% …
Read MoreToxicology • Quaternary ammonium compounds (QACs) are poorly absorbed by oral route and therefore relatively large amounts are eliminated in faeces (Craig & Stitzel, 1994 cited by IPCS, 1999) • …
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