Toxicology
• Clomazone and isoxaflutole exhibits low mammalian toxicity, the acute oral LD50 was estimated to be greater than 2000 mg/kg b (Shah PV and Solecki RA, 2013;Van SAR and Tjeerdema RS, 2014)
• Studies have shown that it inhibits acetylcholinesterase and catalase activities(Van SAR and Tjeerdema RS, 2014)
• They are competitive inhibitors of protoporphyrinogen oxidase (Protox) thus causing protoporphyrin IX accumulation which form s free radicals that lead to membrane disruption or lipid peroxidation ( (Dayan et al 1997) • Isoxaflutole principally inhibits carotenoid synthesis through antagonism of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD) that convert 4-hydroxyphenylpyruvate to homogenatisate . . .
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