Toxicology
• The primary routes of arsenic exposure are ingestion and inhalation (HPA, 2007;ATSDR, 2009)
• The more efficiently absorbed forms of arsenic the more toxic it is, while those efficiently eliminated tend to be less toxic(ATSDR, 2009)
• The soluble pentavalent and trivalent arsenic such as arsenious acid and sodium arsenite are rapidly and extensively absorbed from the gastrointestinal tract (HPA, 2007;ATSDR, 2009)
• The metabolism of arsenic entails reduction of Pentavalent arsenic to trivalent forms then sequentially O-methylated to form mono-, di- and trimethylated products using S-adenosyl methionine as the methyl donor and glutathione as an essential . . .
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