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Specific Management

Acute Toxic Agents / Chemical Class / Specific Management

PHOSPHONATES

November 9, 2017April 1, 2026 - by Poison Sense

 Toxicology  The mechanism of toxicity of glyphosate in mammals is unknown, but may be the uncoupling of oxidative phosphorylation (Beswick and Millo, 2011). Mechanisms of toxicity of glyphosate formulations are …

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Acute Toxic Agents / Chemical Class / Specific Management

PARACETAMOL

November 9, 2017June 9, 2023 - by Poison Sense

Toxicology Paracetamol is rapidly absorbed from the small intestine (Peak serum conc within 1–2 hrs for standard tablet and within 30 minutes for liquid preparations (Ministry of Health of Singapore, …

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Acute Toxic Agents / Chemical Class / Specific Management

Beta-KETONITRILE

November 9, 2017December 15, 2025 - by Poison Sense

Toxicology • Beta-ketonitriles includes Cyenopyrafen, Cyflumetofen. Beta-ketonitrile group is highly selective and causes poisoning through inhibition of the mitochondrial electron transport complex II enzyme within mite cells. Since complex II, …

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Acute Toxic Agents / Chemical Class / Specific Management

CYCLOHEXENONE DERIVATIVES

November 9, 2017December 15, 2025 - by Poison Sense

Toxicology The cyclohexanediones has-been shown to inhibit lipid biosynthesis in plants possibly through inhibition of acetyl-CoA carboxylase involved in fatty acid synthesis (Secor and Cseke, 1988). Cyclohexanediones includes alloxydim butroxydim …

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Acute Toxic Agents / Chemical Class / Specific Management

HYDROGEN CYANIDE

November 9, 2017May 4, 2025 - by Poison Sense

Toxicology Hydrogen cyanide, a highly volatile, colourless, and extremely poisonous liquid (boiling point 26° C). Hydrogen cyanide and its compounds are used for many chemical processes, including fumigation, the case …

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Acute Toxic Agents / Chemical Class / Specific Management

SILICON

November 9, 2017June 9, 2023 - by Poison Sense

Toxicology Silicon, does not exist naturally in its pure form but reacts with oxygen and water to form silicon dioxide. Silicon dioxide has two naturally occurring forms: crystalline and amorphous. …

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Acute Toxic Agents / Chemical Class / Specific Management

QUINOLIZIDINE ALKALOID

November 9, 2017December 19, 2025 - by Poison Sense

Toxicology • Cytisine, a tricyclic quinolizidine alkaloid found in Baptisia, Cytisus, Laburnum, and Sophora species, has nicotinelike effects on the gastrointestinal (GI) tract and the central nervous system (CNS). • …

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Acute Toxic Agents / Chemical Class / Specific Management

PYRETHRINS & PYRETHROID

November 9, 2017June 9, 2023 - by Poison Sense

Toxicology • Pyrethroids are synthetic derivatives of natural pyrethrins. Pyrethroids can be Type I(e.g., allethrin, resmethrin, D-phenothrin, and permethrin) or Type II (e.g., deltamethrin, cypermethrin, cyfluthrin and fenvalerate) based on …

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Acute Toxic Agents / Chemical Class / Specific Management

ISOXAZOLE HERBICIDES

November 9, 2017December 19, 2025 - by Poison Sense

Toxicology • Clomazone and isoxaflutole exhibits low mammalian toxicity, the acute oral LD50 was estimated to be greater than 2000 mg/kg b (Shah PV and Solecki RA, 2013;Van SAR and …

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Acute Toxic Agents / Chemical Class / Specific Management

CALCIUM CHANNEL BLOCKERS

November 9, 2017June 9, 2023 - by Poison Sense

Toxicology Calcium channel blockers (CCBs) are generally classified into two groups: dihydropyridines (nifedipine, nicardipine, amlodipine,clevidipine etc) and non-dihydropyridines (verapamil, diltiazem). Calcium has a prominent role in cardiovascular function. The flow …

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Hi, I am Dr. Bundo, Msc in pharmacology and Toxicology.
This site is here to bring clinical toxicology information to the public domain.

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