Toxicology
• Beta-ketonitriles includes Cyenopyrafen, Cyflumetofen.
Beta-ketonitrile group is highly selective and causes poisoning through inhibition of the mitochondrial electron transport complex II enzyme within mite cells. Since complex II, the target of cyflumetofen is part of the Krebs cycle, where NADH is generated from NAD+ produced by complex I, blocking either complex inhibits most electron transport. This inhibition stops the production of ATP, rapidly depleting the cellular energy, which in turn leads to loss of motor coordination, paralysis and death(BASF Agricultural Products;PPDB, 2015)
• It shows a low oral, dermal, and inhalation acute toxicity(Acute oral LD50 . . .
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