Toxicology
• Structurally diverse synthetic insecticides and acaricides had been shown to inhibit the proton-translocating NADH:ubiquinone oxidoreductase (complex I) activity (Lummen P, 1998).
• The acute toxicity profile of pyridaben is moderate to low (LD50 570-1350mg/kg) (Igarashi and Sakamoto, 1994)
• The mechanism of action is thought to be inhibition of electron transport chain and more specifically of complex I (NADH:ubiquinone oxidoreductase), electron acceptor of complexes I and II is ubiquinone (Q_10). This inhibits the formation of the proton gradient required for ATP production (National Center for Biotechnology Information)
• It is thought to interfere or block electron transport . . .
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