Toxicology
• Cytisine, a tricyclic quinolizidine alkaloid found in Baptisia, Cytisus, Laburnum, and Sophora species, has nicotinelike effects on the gastrointestinal (GI) tract and the central nervous system (CNS).
• Neurologic effects range from relaxation and euphoria to seizures
• These alkaloids produces vasodilatory effects
• The toxicity is characterized by nicotinoid, anticholinergic, or opioid toxidrome
• The mechanism underlying its toxicity is not well elucidated but some studies have reported interference with biosynthesis (Wink and Twardowski, 1992) • Cytisine and probably other quinolizidine alkaloids are strong agonist at acetylcholine receptors (Boska and Quiron, 1987 Other targets includes K+ channels and glutamate receptors
Clinical Manifestation
• Nausea . . .
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