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Specific Management

Acute Toxic Agents / Chemical Class / Specific Management

CHLOROACETANILIDE HERBICIDES

October 30, 2017April 24, 2025 - by Poison Sense

Toxicology The commonly used herbicides are alachlor, acetochlor, butachlor, metolachlor, and propachlor. This class of herbicides is slightly hazardous, except butachlor, which is not likely to pose any hazard. Chloroacetanilides …

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Acute Toxic Agents / Chemical Class / Specific Management

SAFROLE

October 30, 2017January 2, 2026 - by Poison Sense

Toxicology • The major target organ of piperonyl butoxide(PBO) is the liver.Histopathological effects including enlargement of hepatocytes with glassy cytoplasm, oval cell proliferation, bile duct hyperplasia, and focal necrosis were …

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Acute Toxic Agents / Chemical Class / Specific Management

BETA-2 RECEPTOR AGONISTS

October 30, 2017June 8, 2023 - by Poison Sense

 Toxicology Beta-2 adrenergic agonists includes Bitolterol, Formoterol, Metaproterenol, Pirbuterol, Salbutamol (Albuterol), Salmeterol, Terbutaline among others • beta-2receptor agonists causes increased heart rate in sinoatrial node (SA node) in addition to …

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Acute Toxic Agents / Chemical Class / Specific Management

BENZONITRILE HERBICIDES

October 30, 2017December 12, 2025 - by Poison Sense

 Toxicology • Some nitriles such as Bromoxynil Octanoate are moderately acutely toxic (Oral LD50, 50-500 mg/kg) (Kegley et al 2014). • The principal toxic action of the benzonitriles eg Bromoxynil …

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Acute Toxic Agents / Chemical Class / Specific Management

CHLOROPHENOXY COMPOUNDS

October 30, 2017December 12, 2025 - by Poison Sense

Toxicology Chlorophenoxy herbicides contain an aliphatic carboxylic acid moiety attached to a chlorine-or-methyl-substituted aromatic ring. Representative compounds of this class include 2,4-dichlorophenoxy acetic acid; 2, 4-dichlorophenoxy propionic acid; 2,4,5-trichlorophenoxy acetic …

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Acute Toxic Agents / Chemical Class / Specific Management

COPPER SALTS & ORGANIC COMPLEXES

October 30, 2017June 8, 2023 - by Poison Sense

Toxicology • Copper sulphate is a powerful oxidizing agent and a corrosive acid to mucous membranes (Saravu et al 2007). • The soluble copper salts such as CuSO4 show limited …

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Acute Toxic Agents / Chemical Class / Specific Management

Snakebite Envenomation & Management

October 30, 2017April 4, 2026 - by Poison Sense

Toxicology The composition of snake venom from a single species of venomous snake can consist of up to 100 different toxic elements, including enzymes (constituting 80-90% of viperid; 25-70% of …

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Acute Toxic Agents / Chemical Class / Specific Management

BIPYRIDYL HERBICIDES

October 30, 2017July 1, 2024 - by Poison Sense

Toxicology Bipyridyl (or bipyridinium) herbicides are quaternary ammonium compounds marketed as contact herbicides and desiccants (Eddleston M. 2016). Bipyridyl herbicides-diquat and paraquat-exist as divalent cations found as dibromide or dichloride …

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Acute Toxic Agents / Chemical Class / Specific Management

BETA-RECEPTOR BLOCKERS

October 30, 2017June 8, 2023 - by Poison Sense

 Toxicology Beta-blockers act as competitive inhibitors of catecholamines at both central and peripheral receptors. Blockade of beta-receptors results in decreased production of intracellular cAMP  which in turn suppresses multiple metabolic …

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Acute Toxic Agents / Chemical Class / Specific Management

VITAMIN K ANTAGONISTS

October 30, 2017June 8, 2023 - by Poison Sense

Toxicology Superwarfarins such as  brodifacoum, bromadiolone, chlorophacinone, difenacoum and difethialone are long acting, odourless, tasteless and colourless hydroxycoumarin  rodenticides. They affect regeneration of Vit K. Reduced vitamin K (hydroquinone) is a …

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Hi, I am Dr. Bundo, Msc in pharmacology and Toxicology.
This site is here to bring clinical toxicology information to the public domain.

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