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Associated with impairment of normal cooling mechanisms such as sweating Treatment: Supportive care including active cooling and benzodiazepines NOTE: It is difficult to differentiate the toxic hyperthermic syndromes including hyperthermia …
Read MoreTriad of hyperthermia, muscle rigidity, and metabolic acidosis – Occurs in genetically susceptible individuals (both autosomal dominant and recessive inheritance patterns) – Triggered by general anaesthetics (volatile gases, succinylcholine) – …
Read MoreIt is an idiosyncratic reaction (not related to dose or duration) to certain medications, mostly neuroleptics, within 7 days (4 weeks with depot preparations). Mechanisms Pathophysiology most likely includes acute …
Read MoreSympathomimetic fever Sympathomimetics, such as amphetamines and cocaine, may produce hyperthermia due to excess serotonin and dopamine resulting in thermal deregulation Treatment is supportive including active cooling and benzodiazepine Uncoupling …
Read MoreHyperthermia is defined as an uncontrolled rise of core body temperature above 38°C, at which temperature the human body is unable to lose heat. In drug induced hyperthermia, the core …
Read MoreHypotension is systolic blood pressure less than 90 mm Hg in adults (with normal parameters adjusted in children depending on age and weight). Bradycardia is a heart rate lower than …
Read MoreAcute acidosis such as due to formic acid from methanol poisoning, lactic acidosis and ketoacidosis CLINICAL MANIFESTATION • Disruption of electrical activity of the heart causes arrhythmias • 8-9 mEq/l …
Read MorePotassium loss is accompanied by chloride loss Alkalosis increases cellular uptake of potassium • Excessive doses of insulin increases cellular uptake of potassium • Severe fluid loss through vomiting, diarrhea …
Read More•Cause of metabolic alkalosis includes: May be due to net loss of H+ through either the kidney (loss of H+ causes a gain HCO3-, which may occur due to volume …
Read MoreOVERVIEW Elevated blood pressure in the poisoned patient may or may not be the result of exposure to any toxicant. Other causes of elevated blood pressure may include benzodiazepine or …
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