Sympathomimetic fever
Sympathomimetics, such as amphetamines and cocaine, may produce hyperthermia due to excess serotonin and dopamine resulting in thermal deregulation
Treatment is supportive including active cooling and benzodiazepine
Uncoupling syndrome
Uncoupling syndrome occurs when the process of oxidative phosphorylation is disrupted leading to heat generation
Drugs: salicylate poisoning; indicates a need for dialysis
Serotonin syndrome
Results from excess serotonin at both peripheral and central serotonergic receptors
Presents with hyperthermia, altered mental status and neuromuscular abnormalities (rigidity, hyperreflexia, clonus)
Causes: Therapeutic dose or overdose of serotonergic agents: antidepressantsa and other serotonin enhancing drugs and . . .
Please Subscribe to continue reading
