It is an idiosyncratic reaction (not related to dose or duration) to certain medications, mostly neuroleptics, within 7 days (4 weeks with depot preparations).
Mechanisms
Pathophysiology most likely includes acute alterations and reduction of central dopaminergic activity via antagonism of dopamine receptors (D2) or lower synaptic dopamine concentrations.
NMS has been observed in Parkinson's patients when dopamine agonists such as levodopa are suddenly withdrawn
May occur as a result of a rapid increase in dose of neuroleptics, especially the long-acting ones (Oruch et al., 2017).
May be caused by centrally acting antiemetics
Dopamine blockade in the . . .
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