Triad of hyperthermia, muscle rigidity, and metabolic acidosis
- Occurs in genetically susceptible individuals (both autosomal dominant and recessive inheritance patterns)
- Triggered by general anaesthetics (volatile gases, succinylcholine)
- Hypermetabolic state induced in skeletal muscle
- Mortality decreased from 90% to 7 % with appropriate treatment
- Muscle biopsies can be used to test for susceptibility
- Disordered calcium regulation in skeletal muscle fibres may play a role in the pathophysiology of MH. There is decreased ability to retain and regulate calcium in the sarcoplasmic reticulum.
Increased intacellular calcium may lead to excessive and prolonged muscle contraction with resulting excessive heat production
Increased calcium also uncouples . . .
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