Clethodim is a selective, post-emergence cyclohexanedione herbicide widely used to control a broad spectrum of annual and perennial grass weeds. Its herbicidal activity results from inhibition of acetyl-CoA carboxylase (ACCase), a key enzyme involved in fatty acid and lipid biosynthesis in susceptible plants. By disrupting lipid production, clethodim impairs cell membrane formation and other essential metabolic processes, leading to growth cessation and eventual death of affected grass species.
Clethodim is extensively absorbed (88-95% of the administered dose irrespective of dose regimen) and widely distributed in the body, with the highest residues in the adrenals, liver, and kidneys . . .
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