Toxicology
• Included in this group are benomyl, thiabendazole, thiophanate,thiophanate-methyl, carbedazim, Imazalil and fuberidazol (Rouabhi R, 2010)
• Benomyl and carbendazim show low acute toxicity (Oruc HH, 2010).
Benomyl is metabolised invivo to carbendazim (Oruc HH, 2010).
• LD50 of benomyl is estimated to be higher than 10000mg/kg while for carbendazim is 15000mg/kg (Rouabhi R, 2010)
• The rat oral LD50 of thiabendazole is 3,100-3,600 mg/kg
• Fuberidazole has moderate toxicity with an LD50 336mg/kg (Oruc HH, 2010)
• Many compounds in this group, inhibit mitochondrial fumarate reductase, reduce glucose transport and uncouple oxidative phosphorylation (Rouabhi R . . .
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