Toxicology
• Chlorfenapyr is a pro-compound that is activated insitu by oxidative removal of the N-ethoxymethyl group of chlorfenapyr by mixed-function oxidases to form the compound CL 303268 which may partly explain the delayed nature of its toxicity (USEPA, 2001;Tharaknath, 2013;Lee et al 2013).
• Inhibitiors of cyp450 enzyme such as piperonyl butoxide antagonizes the effects of chlorfenapyr (Tharaknath, 2013).
• The resultant metabolite is responsible for uncoupling oxidative phosphorylation by disrupting the proton gradient across mitochondrial membranes, thereby reducing energy production by blocking conversion of ADP to ATP (USEPA, 2001;Choi et al 2010;Tharaknath, 2013;Ku . . .
Please Subscribe to continue reading
