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Author: Poison Sense

PoisonSense Blog

WHY SERUM CREATININE IS A POOR MEASURE IN GERIATRICS

June 13, 2023 - by Poison Sense

The elderly generally have a reduced muscle mass. Since creatinine is a metabolic product of muscle proteins, the diminished muscle mass in the elderly significantly affect the reliability of serum …

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PoisonSense Blog

WITH ALCOHOLIC DRINKS, WOMEN ARE THE WEAKER SEX  

June 13, 2023 - by Poison Sense

Alcohol is a small water- soluble molecule. It distributes rapidly into all body water so that its concentrations in blood approximates that in other tissues. Since women have lower body …

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PoisonSense Blog

WHY DIAZEPAM IS OFTEN USED IN ALCOHOL WITHDRAWAL SYNDROME

June 13, 2023 - by Poison Sense

It is cheap and widely available. It has a wide margin of safety, and thus very high doses can be used without any major risk of toxicity. It has a …

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PoisonSense Blog

WHEN PROSTAGLANDINS ARE PREFERRED TO OXYTOCIN

June 13, 2023 - by Poison Sense

PGE2 (e.g Dinoprostone) and PGF2alfa (e.g. Carboprost) are theoretically superior to oxytocin for inducing labour in women with eclampsia, preeclampsia and other cardiovascular diseases because, unlike oxytocin that is intrinsically …

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PoisonSense Blog

FACTS ABOUT LEAD POISONING

June 13, 2023 - by Poison Sense

Lead is highly toxic with no known safe level for anyone to eat, drink or breathe in. The major sources of lead are lead-based paint, leakages from lead-coated pipes in …

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PoisonSense Blog

WHAT YOU SHOULD KNOW ABOUT CARBON MONOXIDE POISONING

June 13, 2023 - by Poison Sense

Carbon monoxide (CO) is a Colorless, tasteless, odorless, and non-irritating gas. Thus, it’s presence cannot be detected by people at risk of its poisoning. Detection is made much more difficult …

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WHY ADMINISTERING AN IV DRUG TOO QUICKLY MAY BE DANGEROUS

June 13, 2023 - by Poison Sense

1. Too rapid administration of drugs having a high volume of distribution results in a transiently toxic blood concentrations that may injure or overstimulate organs such as the heart to …

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PoisonSense Blog

SEVERE DIARRHOEA AND DIGOXIN TOXICITY 

June 13, 2023June 13, 2023 - by Poison Sense

Did you know that patients on long term use of digoxin could experience severe digoxin toxicity if they suffer severe fluid loss through intense vomiting and diarrhea? Such a toxicity …

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PoisonSense Blog

WHY YOU WANT TO CONSIDER ATYPICAL ANTIPSYCHOTICS FOR PSYCHOSIS

June 13, 2023June 13, 2023 - by Poison Sense

For most patients with schizophrenia and bipolar disorder with psychotic features, typical and atypical antipsychotics (eg chlorpromazine, haloperidol) are of equal efficacy for treating positive symptoms (Feelings or behaviors that …

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PoisonSense Blog

WHY ORAL GLUCOSE PROVOKE LESS HYPERGLYCEMIA THAN INTRAVENOUS GLUCOSE?

June 13, 2023 - by Poison Sense

Oral glucose, unlike intravenous glucose, enhances secretion of endogenous insulin secretagogues which then amplify the glucose- induced insulin secretion. So, for the same amount of glucose, parenterally administered glucose is …

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Hi, I am Dr. Bundo, Msc in pharmacology and Toxicology.
This site is here to bring clinical toxicology information to the public domain.

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