JUST AS THERE ARE PRODRUGS, THERE ARE PROPOISONS
Certain poisons are harmless until they are biotransformed in the body to active metabolites. What are their properties? 1. They exhibit a delayed onset of action. A latent period for …
Read MoreAuthor: Poison Sense
TREATMENT OF PYRETHROID POISONING
Treatment of poisoning caused by pyrethroids is informed by their mechanism of action. Pyrethroids increase neuronal excitability by not only affecting the ubiquitous voltage- sensitive sodium channels but also by …
Read MoreWHY IT IS IMPORTANT TO KNOW THE TOXICOLOGY OF A TOXIC AGENT
1. GIT AND SKIN ABSORPTION: If it is well absorbed dermally, the skin must be promptly washed with clean water. If it is poorly absorbed orally, activated charcoal and saline …
Read MoreWHY HEPARIN IS TRANSIENTLY USED IN WARFARIN THERAPY
Warfarin- mediated hemostasis is achieved by the balance of inhibition of procoagulant factors VII, IX, X, and II, and anticoagulant factors C. The half-Life of anticoagulant factors C is shorter …
Read MoreWHY LOW DOSE ASPIRIN IS USED TO PREVENT THROMBOTIC EVENTS
Thromboxane A2 is a prostaglandin involved in the clotting process through platelet aggregation and amplifying the effects of thrombin Thromboxane A2 is the major synthetic products of cyclooxygenase-1 ( COX-1) …
Read MoreFACTS ABOUT A POPULAR ACARICIDE IN THE NORTHRIFT; DUODIP
“Duo” means two. The acaricide has two insecticidal components;organophosphates and pyrethroids. Chlorpyrifos (organophosphate) acts independently and synergistically with cypermethrin (pyrethroid). The symptoms of Duodip poisoning is dependent largely on the …
Read MoreSELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs
Are chemically unrelated class of antidepressants that majorly inhibits serotonin transporter (SERT) thereby causing increased synaptic serotonin. Includes fluoxetine, sertraline, paroxetine, citalopram and fluvoxamine SSRIs have broad indications including major …
Read MoreWHY IT IS DISASTROUS TO CHRISTEN EVERY POISONING OPP
Chromoxone, herbikill, partner etcetera are paraquat herbicides of bipyridyl group used widely by farming communities. They do not affect the nervous system like Opp. They instead cause oxidative destruction of …
Read MoreNSAID PAINKILLERS AND BONE FRACTURE
Prostaglandins are chemicals synthesized in the body for various biological functions. Some of the prostaglandins, particularly PGE2, synthesized by bone and skeletal muscle tissues are involved in bone homeostasis ie …
Read MoreIBUPROFEN OVERDOSE
Ibuprofen is usually used to relieve fever, pain and/or swelling or inflammation. Toxicity of ibuprofen overdose results from non-specific reversible inhibition of cyclooxygenase I and II, an enzyme responsible for …
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