Thromboxane A2 is a prostaglandin involved in the clotting process through platelet aggregation and amplifying the effects of thrombin
Thromboxane A2 is the major synthetic products of cyclooxygenase-1 ( COX-1)
Aspirin, acetyl salicylic acid, irreversibly acetylates and hence inhibit COX enzyme activity
High dose aspirin acetylates and inhibit non-selectively COX-1and COX-2. However, Low doses (<100mg/d) inhibit synthesis of Thromboxane A2 by preferentially inhibiting platelet COX-1.
Thus, chronic use of low dose aspirin irreversibly inhibit platelet activation and aggregation.
Other salycilates and NSAIDS such as diclofenac, indomethacin and ibuprofen are not used because they . . .
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