Menorrhagia is the medical term for menstrual periods with abnormally heavy or prolonged bleeding.
Prolonged low-dose aspirin used in the management of cardiovascular diseases- heart attack, angina and stroke-irreversibly block the formation of paracrine hormone Thromboxane A2 (TXA2) in platelets, for the lifetime of the affected platelet (8–9 days). TXA2 is an important mediator of blood clotting processes through platelet activation and platelet aggregation in addition to vasoconstriction effects. Vasoconstriction limits the blood loses after vascular endothelial injuries.
The antiplatelet effects of aspirin is magnified by the unchecked anticlotting system by prostacyclin (PGI2). The net effect is increased bleeding tendencies in chronic users of aspirin.
In such a scenario it’s conceivable that the menstruation will be unusually heavy and a long experience.
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