Are chemically unrelated class of antidepressants that majorly inhibits serotonin transporter (SERT) thereby causing increased synaptic serotonin.
Includes fluoxetine, sertraline, paroxetine, citalopram and fluvoxamine
SSRIs have broad indications including major depression; anxiety disorders, premenstrual dysphoric disorders; flushing in perimenopausal women; sexual disorders such as premature ejaculations and bulimia.
Antidepressants achieves maximum benefit after 1-2 months in 30-40% of patients. So, increase in dosage or addition of another agent may be necessary.
SSRIs show several advantages over other antidepressants including ease of use ( doesn't require dose titration), tolerability, safety in overdose (least effects on histamine and muscarinic receptors . . .
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