Prostaglandins are chemicals synthesized in the body for various biological functions.
Some of the prostaglandins, particularly PGE2, synthesized by bone and skeletal muscle tissues are involved in bone homeostasis ie bone resorption and formation and repair of skeletal muscle injury.
The synthesis of these important chemicals are suppressed by painkillers of NSAIDS class such as high dose Aspirin, Ibuprofen, Indomethacin and Diclofenac.
NSAID- induced prostaglandin synthesis suppression thus impairs and delay bone fracture healing.
You are thus well advised to use alternative painkillers to manage pain in bone fracture.
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