Certain poisons are harmless until they are biotransformed in the body to active metabolites.
What are their properties?
1. They exhibit a delayed onset of action. A latent period for activation of poison is required before symptoms are discernible, thus poisoning could easily be missed or dismissed if the patient presents soon after exposure.
2. They show a prolonged duration of action. Patients should be admitted for observation. Relapse is common.
3. Inhibitors of hepatic enzyme activity may be antidotal. In contrast, enzyme inducers such as anticonvulsants and some TB/HIV medications may accelerate toxication.
6. Propoisons that are widely distributed in the body I.e. of high lipophilicity and/or extensive protein binding show high relapse rate thus demands for extended period of hospitalization for close monitoring
What are some of these poisons?
Organophosphates with thio group such as diazinon, malathion , dimethoate and fenthion
Methanol
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