BENZENOIDS

Toxicology
• Metalaxyl is a slightly toxic compound in EPA toxicity class III (oral LD50 in rats is 669 mg/kg) (E X T O X N E T, 1996)
• Studies with rats and goats showed thart metalaxyl is rapidly metabolised and excreted via the urine and feces (E X T O X N E T, 1996)
• Metalaxyl exposure to laboratory animals produced haematological and biochemical abrrations possibly due to an induced oxidative stress (Al-Amoudi WM, 2012)

Clinical Manifestation
• Decrease in RBC counts, haemoglobin content and blood platelet counts (Al-Amoudi WM, 2012)
Increase in WBC counts(Al-Amoudi WM . . .

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