Toxicology
- In plants these herbicides inhibit protophorphyrinogen oxidase (Protox), leading to accumulation of protoporphyrinogen (protogen). Protogen is oxidized to protoporphyrin IX (which is activated by light and causes formation of reactive oxygen species resulting in oxidative membrane degradation and plant death)(National Library of Medicine, 2001).
- This is the mechanism thought to pose a theoretical risk of variegate porphyria or transient porphyria cutanea tarda-like syndrome in humans following very large acute exposures (National Library of Medicine, 2001).
- Variegate porphyria (VP) is a rare, inherited disorder caused by a deficiency in the enzyme protoporphyrinogen . . .
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