Toxicology
• The major target organ of piperonyl butoxide(PBO) is the liver.Histopathological effects including enlargement of hepatocytes with glassy cytoplasm, oval cell proliferation, bile duct hyperplasia, and focal necrosis were observed in subchronic studies in rats (USEPA).
• The Mode of Action piperonyl butoxide(PBO) inhibits liver mixed function oxidases in target organisms by direct binding to these enzymes thereby inhbiting the break down of other pesticides including pyrethrins and pyrethroid, rotenone, carbamates and organophosphates (USEPA;National Library of Medicine HSDB database, 2010).
• However, enzyme inhibition in mammals is reportedly transient and exhibits biphasic effects, i.e., initial inhibition followed . . .
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