Toxicology
• Some nitriles such as Bromoxynil Octanoate are moderately acutely toxic (Oral LD50, 50-500 mg/kg) (Kegley et al 2014).
• The principal toxic action of the benzonitriles eg Bromoxynil Octanoate is uncoupling of mitochondrial oxidative phosphorylation(NIH U.S. National Library of Medicine National Center for Biotechnology Information, 2015).
• Aromatic nitriles, unlike aliphatic nitriles, do not appear to liberate cyanide within the body (MSDS, 2010)
• Although benzonitriles are not as dangerous as hydrogen cyanide and sodium cyanide, it can cause cyanide poisoning (Sparchem, 2015;MSDS, 2010).
Clinical Manifestation
•SIGNS of uncoupler poisoning(NIH U.S. National Library of Medicine . . .
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