15 POINTS ABOUT CASSAVA POISONING
1. Cassava does not contain cyanide per se but contain cyanogenic glycosides that when eaten or processed are converted to cyanide. The exact amount of cyanogenic glycosides in a plant …
Read MorePoisonSense Blog
MAD HONEY DISEASE: INTOXICATING/POISONING EFFECTS, AND TREATMENT
Consumption of honey containing toxins can lead to poisoning/intoxication. There are two types of honey intoxication/poisoning. Consumption of honey containing grayanotoxins (polyhydroxylated cyclic hydrocarbon structures that do not contain nitrogen) …
Read MoreOverdose of Tenofovir Lamivudine Efavirenz Fixed-dose Combination therapy
A typical antiretroviral regimen includes a “backbone” of two nucleoside reverse transcriptase inhibitors (NRTI) such as Tenofovir and Lamivudine and a “base” of either a protease inhibitor (PI) (lopinavir, atazanavir …
Read MoreWhy prolonged paralysis and apnoea may be a complication in anaesthetized pesticide handlers
Pesticide intoxications carry obvious risks of several secondary symptoms when drugs that are substrates to a target enzyme are administered. Organophosphate pesticides and drugs act primarily by inhibiting irreversibly acetylcholinesterase …
Read MoreWhy adulteration of meals in boarding schools with kerosene is bad for teen health
The use of crude kerosene has been a common practice in Kenyan schools for many years, with the false belief that it reduces the sex drive (libido) of teenagers. Small …
Read MoreWhat clinicians need to know about phenobarbital overdose
Barbiturates including phenobarb suppress the medullary respiratory center to induce respiratory depression. Patients with underlying chronic obstructive pulmonary disease are more susceptible to respiratory depression even at doses that are …
Read MoreOgilvies syndrome: (Un)common complication of amitraz poisoning
Ogilvie’s syndrome, also known as acute colonic pseudo-obstruction (ACPO), is a paralytic ileus of the colon that is characterized by massive colonic distension in the absence of mechanical obstruction. If …
Read MoreDrug and drug combinations after severe asthma attack
Asthma is a chronic inflammatory disorder of the airways. Inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing particularly at night and early morning. Asthma can be classified …
Read MoreMechanism of Mitotoxicity
A major factor that determines organ-specific toxicity first is pharmacokinetics, absorption, distribution, metabolism, excretion (ADME). That is, If a chemical is not delivered to a tissue for pharmacokinetic reasons, then …
Read MoreWhat to know about magnesium sulphate inj
Magnesium plays an important role in neurochemical transmission and muscular excitability. The mechanism of action of magnesium sulfate is not as well described but is thought to competitively block intracellular …
Read More