A major factor that determines organ-specific toxicity first is pharmacokinetics, absorption, distribution, metabolism, excretion (ADME).
That is, If a chemical is not delivered to a tissue for pharmacokinetic reasons, then it will not have a significant effect in that tissue.
There are several mechanisms by which mitochondria can be adversely affected by chemical compounds
(a) inhibition of one or more of the electron transport chain complexes;
(b) uncoupling of mitochondrial oxidative phosphorylation by dissipation of the membrane potential and thus disconnecting the ETC from ATP synthase through the loss of the inner mitochondrial membrane impermeability. It results in the . . .
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