Toxicology
Paracetamol is rapidly absorbed from the small intestine (Peak serum conc within 1–2 hrs for standard tablet and within 30 minutes for liquid preparations (Ministry of Health of Singapore, 2011). About 10% of absorbed paracetamaol is metabolized via cytochrome P450 (chiefly 2E1 and 3A4) into the highly reactive intermediary compound N-acetyl-p-benzoquinone imine (NAPQI), that is detoxified by conjugation with glutathione and eliminated in the urine as mercapturic adducts (Ministry of Health of Singapore, 2011). In overdose, hepatic stores of glutathione are exhausted and NAPQI binds to other proteins thereby inducing hepatic cell death or necrosis . . .
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