Toxicology
- Calcium channel blockers (CCBs) are generally classified into two groups: dihydropyridines (nifedipine, nicardipine, amlodipine,clevidipine etc) and non-dihydropyridines (verapamil, diltiazem).
- Calcium has a prominent role in cardiovascular function. The flow of calcium across cell membranes is necessary for cardiac automaticity, conduction and contraction, as well as maintenance of vascular tone (DeWitt and Waksman, 2004).
- Calcium blockers block the movement of calcium into cell membranes through inhibition of the voltage-sensitive L-type calcium channels. In so doing, prevents movement of calcium into the cell, which limits the release of calcium that is . . .
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