Toxicology
• The acute toxicity profile of pyridaben is moderate to low (LD50 570-1350mg/kg) (Igarashi and Sakamoto, 1994)
The mechanism of action is thought to be inhibition of electron transport chain and more specifically of complex I (NADH:ubiquinone oxidoreductase), electron acceptor of complexes I and II is ubiquinone (Q_10). This results in preventing the formation of the proton gradient required for ATP production (National Center for Biotechnology Information)
. Slightly less than half of orally administered pyridaben is absorbed which is the excreted primarily through bile and hence in feces (Igarashi and Sakamoto, 1994;National Center for Biotechnology Information . . .
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