Toxicology
• Although the exact mechanism of toxicity is not elucidated, it is thought to inhibit the production of the enzyme chitin synthase during molting of immature stages of arthropods
• The systemic toxicity of diflubenzuron is low (National library of medicine HSDB database, 2014).
• Novaluron is reportedly of slight toxic potential (oral LD greater than 500mg/kg bw) (Pesticide toxicity table, 2012)
• Lufenuron has been determined to be slightly hazardous Oral LD50 mg/kg bwt in rat is>2000 (Central Agricultural Pesticides Laboratory, 2009)
• Methemoglobinemia from diflubenzuron metabolite 4-chloroaniline has been reported
Clinical Manifestation
• Methemoglobinemia (National library of medicine . . .
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