Toxicology
- The most severe adverse effects of fluoroquinolones (FQs) include toxicities of the gastrointestinal tract, central nervous system, cardiovascular system, and musculoskeletal system.
- The commonest adverse events are gastrointestinal tract and central nervous system (CNS) reactions; nephrotoxicity and tendinitis are infrequent. Different agents also show greatly varying phototoxic potential.
- FQs can survive inside the cell for many years, resulting in chronic long-term adverse reactions in patients (Pietruszyński et al., 2020).
- Fluoroquinolones seem to cause musculoskeletal injury, by binding to the collagen matrix of many tissues (tendons, vessels), in three pathways . . .
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